POS1076 APICAL FIBROSIS AND INTERSTITIAL LUNG DISEASE IN PATIENTS WITH PSORIATIC ARTHRITIS: DO WE UNDERESTIMATE?

Background: Extra-articular manifestation (EAMs) definition is not clearly defined in psoriatic arthritis (PsA). Nail involvement, enthesitis, dactylitis has been widely studied however, data are needed on pulmonary involvement PsA. Objectives: We aimed to understand real-life results of lung PsA patients. Methods: From the cohort followed our outpatient clinic, patients who have requested a chest computed tomography (CT) for any reason by department were retrieved from medical records and included this retrospective cross-sectional analysis. All CTs assessed radiologist blinded patients` clinical history findings categorized as parenchymal, airway, pleural lymphadenopathy (LAM). Moreover, that radiologically attributed specific entity such previous tuberculosis (Tb) infection noted. Demographic/clinic including smoking status, concomitant problems, disease characteristics (duration, axial/ peripheral involvement) collected analyzed. Results: A total 80/1072 (7.4 %; 65% female) with mean (SD) age 56.1 (13.2) years study. Median (IQR) duration was 23.5 (55.75) months 36 (45%) had peripheral, 29 (36.3%) axial involvement. For rest 15 (18.7 %) patients, radiographic assessment missing. Smoking status could be 47 (never=40.4%, ex-smoker= 19.1%, current smoker=40.4%). There 14 problem 12 (15%) CT showed 68.8% at least one pathology. Parenchymal seen both non-spesific changes (atelectasis, n= 35; nodules, n=24; ground glass opacity, 9; sequelae fibrosis, emphysema, 7; consolidation, 5, interstitial thickening, 5; cyst, n =4) pathologies apical fibrosis (AF) (n=5) intersititial (ILD) (n=5, NSIP=3, LIP=2). AF linked Tb 1 patient radiotherapy another (Table 1). However, there no pathology 3 (3.7%) all them male. Other airway 28.8% (bronchiectasis, 17, bronchial wall thickness, 10, air trapping 7, centrilobular 4,) 13.8 % (pleural plaque, effusion, 3, n=3). LAM observed around 4% Table 1. Patient Involvement Gender Age duration, Axial Disease (yes/no) Status package-years Concomitant Lung Linked ID-1 M 58 2 No Current 40 ID-2 61 ID-3 73 122 Yes Ex 30 ID-4 F 55 NA * ID-5 65 # Never - € ID-6 NSIP 96 ID-7 69 $ ID-8 66 156 ID-9 LIP 200 ID-10 80 AF= Apical fibrosis; NSIP= Non-spesific pneumonia, LIP= Lymphocytic pneumonia; PsA= Psoriatic Arthritis, NA= Not available*radiotherapy sequelae; done prior diagnosis; infection; chronic obstructive Conclusion: The experience variable spesific, findings. As limitation represent 8% cohort. Within scope reports male predominant ILD come forward requires further attention future studies [1,2]. References: [1]Peluso R, Iervolino S, Vitiello M, et al (2015) manifestations Clin Rheumatol 34 (4):745-753. [2]Bargagli E, Bellisai F, Mazzei MA, (2020) Interstitial associated arthritis: new entity? Intern Emerg Med. Disclosure Interests: None declared.